[1]王丽平,陆承平,唐家琪.猪链球菌对大环内酯类抗生素的耐药性及耐药表型[J].南京农业大学学报,2004,27(4):81-84.[doi:10.7685/j.issn.1000-2030.2004.04.018]
 WANG Li-ping,LU Cheng-ping,TANG Jia-qi.Trends and phenotypes of resistance to macrolides in Streptococcus suis[J].Journal of Nanjing Agricultural University,2004,27(4):81-84.[doi:10.7685/j.issn.1000-2030.2004.04.018]
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猪链球菌对大环内酯类抗生素的耐药性及耐药表型()
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《南京农业大学学报》[ISSN:1000-2030/CN:32-1148/S]

卷:
27卷
期数:
2004年4期
页码:
81-84
栏目:
出版日期:
2004-11-30

文章信息/Info

Title:
Trends and phenotypes of resistance to macrolides in Streptococcus suis
作者:
王丽平陆承平唐家琪
南京农业大学动物医学院,江苏,南京,210095;南京军区军事医学研究所,江苏,南京,210002
Author(s):
WANG Li-ping LU Cheng-ping TANG Jia-qi
College of Veterinary Medicine, Nanjing Agricultural Univerisity, Nanjing 210095, China; Institute of Military Medicine, Nanjing Command, Nanjing 210002, China
关键词:
猪链球菌 大环内酯类抗生素 耐药表型 内在型耐药 诱导型耐药 M型耐药
Keywords:
Streptococcus suis macrolides phenotypes of resistance constitutive phenotype inducible phenotype M phenotype
分类号:
R446.5
DOI:
10.7685/j.issn.1000-2030.2004.04.018
文献标志码:
A
摘要:
采用琼脂两倍稀释法和改良的双纸片法 ,测定了兽医临床分离的 4 0株猪链球菌对部分大环内酯类抗生素、克林霉素、林可霉素、青霉素的体外最小浓度及红霉素耐药菌的耐药表型。实验结果显示 ,猪链球菌对红霉素、罗红霉素、泰乐菌素及替米考星的耐药率分别达 72 5 % (2 9/ 4 0 )、 6 7 5 % (2 7/ 4 0 )、 72 5 % (2 9/ 4 0 )和 6 2 5 % (2 5 / 4 0 ) ,对林可霉素和克林霉素的耐药率高达 6 5 % (2 6 / 4 0 )和 6 2 5 % (2 5 / 4 0 ) ,对青霉素耐药率为 4 0 % (16 / 4 0 ) ;青霉素耐药菌株对其他药物的交叉耐药率显著地高于青霉素敏感株 (P <0 0 5 )。在红霉素耐药菌株中 ,以内在型耐药表型为主 ,占 5 8 6 % (17/2 9) ,诱导型及M型耐药表型各占 2 4 1% (7/ 2 9)和 17 2 % (5 / 2 9) ,而 4 0 % (2 / 5 )的M型耐药菌、 5 8 8% (10 / 17)的内在型耐药菌及 5 7 1% (4/ 7)的诱导型耐药菌同时对青霉素耐药。
Abstract:
A total of 40 veterinary clinical strains of Streptococcus suis were examined for their susceptibility to macrolides, clindamycin, lincomycin and penicillin by an agar dilution method with Mueller Hinton agar plates supplemented with 5% bovine serum. The phenotypes of strains resistance to erythromycin were also evaluated by the improved double disk test with erythromycin(15 μg)and clindamycin(2 μg)discs. The results showed that the rate of resistance to erythromycin, roxthamycin, tolysin, tilmicosin, lincomycin and clindamycin were 72.5%(29/40), 67.5%(27/40), 72.5%(29/40), 62.5%(25/40), 65%(26/40)and 62.5%(25/40), respectively. Penicillin resistance was also found among 40% of the isolates tested. Resistance to the other agents were more common among penicillin-resistant isolates than among penicillin-susceptible ones. Constitutive, inducible and M phenotype of resistance were detected in 58.6%, 24.1% and 17.2% of erythromycin resistant strains, respectively. Whereas, 40% of the M phenotype isolates, 58.8% of the constitutive phenotype strains and 57.1% of the inducible phenotype isolates were all penicillin resistant.

参考文献/References:

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备注/Memo

备注/Memo:
国家973项目子专题(G1999011906)
更新日期/Last Update: 2004-11-30