[1]方星星,刘秀红,丁相卿,等.恩诺沙星在异育银鲫体内的组织分布及消除规律[J].南京农业大学学报,2012,35(4):110-114.[doi:10.7685/j.issn.1000-2030.2012.04.020]
 FANG Xing-xing,LIU Xiu-hong,DING Xiang-qing,et al.Distribution and elimination of enrofloxacin in allogynogenetic silver crucian carp,Carassius auratus gibelio[J].Journal of Nanjing Agricultural University,2012,35(4):110-114.[doi:10.7685/j.issn.1000-2030.2012.04.020]
点击复制

恩诺沙星在异育银鲫体内的组织分布及消除规律()
分享到:

《南京农业大学学报》[ISSN:1000-2030/CN:32-1148/S]

卷:
35卷
期数:
2012年4期
页码:
110-114
栏目:
OA栏目
出版日期:
2012-06-15

文章信息/Info

Title:
Distribution and elimination of enrofloxacin in allogynogenetic silver crucian carp,Carassius auratus gibelio
作者:
方星星1 刘秀红1 丁相卿1 赵文婷1 刘文斌1 陆承平2
1. 南京农业大学动物科技学院,江苏 南京 210095;
2. 南京农业大学动物医学院,江苏 南京 210095
Author(s):
FANG Xing-xing1 LIU Xiu-hong1 DING Xiang-qing1 ZHAO Wen-ting1 LIU Wen-bin1 LU Cheng-ping2
1. College of Animal Science and Technology,Nanjing Agricultural University,Nanjing 210095,China;
2. College of Veterinary Medicine, Nanjing Agricultural University,Nanjing 210095,China
关键词:
恩诺沙星异育银鲫组织分布消除规律
Keywords:
enrofloxacinallogynogenetic silver crucian carptissue distributionelimination regularity
分类号:
S948
DOI:
10.7685/j.issn.1000-2030.2012.04.020
摘要:
在24~26 ℃水温条件下,以10 mg·kg-1剂量,用高效液相色谱法检测组织中药物浓度,研究静脉注射和口服给药后恩诺沙星在健康异育银鲫组织内的代谢分布规律。结果表明:静脉注射后,药物在组织中代谢动力学特征符合二室模型;口服给药后,药物吸收良好,生物利用度(F)为86%,组织药物浓度-时间曲线呈现双峰,推测是由于药物在异育银鲫体内的肠肝循环作用所致。静脉注射和口服两种给药方式下,恩诺沙星在异育银鲫体内均具有良好的组织分布,肾脏、肌肉、肝胰脏、鳃和血液5种组织中的药物浓度时间曲线下总面积(AUC)分别为624.2、965.9、721.8、298.0、239.6 μg·h·mL-1和465.3、343.1、542.9、411.4、205.9 μg·h·mL-1,最大药物浓度(Cmax)分别为33.48、16.91、26.44、18.71 μg·g-1和15.30 μg·mL-1,9.20、5.39、7.78、6.88 μg·g-1和4.50 μg·mL-1;药物在各组织中消除时间较长,消除半衰期(T1/2β)分别为169.0、141.4、113.4、36.7、63.5 h和27.3、49.2、77.0、38.5、62.7 h。结论:恩诺沙星以10 mg·kg-1剂量单次口服给药,对细菌引起的异育银鲫病可以起到较好的治疗作用,但需注意药物残留问题。
Abstract:
The distribution of enrofloxacin(EF)in tissues was investigated after single intravenous(i.v.)and oral(p.o.)administration of 10 mg·kg-1 body weight in allogynogenetic silver crucian carp at 24-26 ℃.The tissue concentration of EF was determined by high-performance liquid chromatography(HPLC).A two-compartment model kinetics was observed following i.v.administration.The plasma concentration-time data following p.o.administration showed a double peak-shaped curve,indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp.The absorption of EF was very good with a bioavailability(F)of 86%.After both administrations,the distribution of drug was extensive,the AUC in kidney,muscle,Hepatopancreas,gill and blood was 624.2,965.9,721.8,298.0,239.6 μg·h·mL-1 and 465.3,343.1,542.9,411.4,205.9 μg·h·mL-1,respectively;the Cmax in five tissues was 33.48,16.91,26.44,18.71 μg·g-1 and 15.30 μg·mL-1,9.20,5.39,7.78,6.88 μg·g-1 and 4.50 μg·mL-1,respectively.The depletion time of EF was considerably long,the T1/2β of drug in five tissues was 169.0,141.4,113.4,36.7,63.5 h and 27.3,49.2,77.0,38.5,62.7 h,respectively.Conclusion:EF administered p.o.at a dose of 10 mg·kg-1 might offer a good option for the treatment of infectious diseases in allogynogenetic silver crucian carp,while its relatively long T1/2β indicated a long withdrawal period.

参考文献/References:

[1] Bowser P R,Wooster G A,Leger J,et al.Pharmacokinetics of enrofloxacin in fingerling rainbow trout(Oncorhynhus mykiss)[J].Journal of Veterinary Pharmacology and Therapeutics,1992,15(1):62-71
[2] Kim M S,Lim J H,Park B K,et al.Pharmacokinetics ofenrofloxacin in Korean catfish(Silurus asotus)[J].Journal of Veterinary Pharmacology and Therapeutics,2006,29:397-402
[3] Koc F,Uney K,Atamanalp M,et al.Pharmacokinetic disposition of enrofloxacin in brown trout(Salmo trutta fario)after oral and intravenous administrations[J].Aquaculture,2009,295:142-144
[4] Lewbart G,Vaden S,Deen J,et al.Pharmacokinetics of enrofloxacin in the red pacu(Colossoma brachypomum)after intramuscular,oral and bath administration[J].Journal of Veterinary Pharmacology and Therapeutics,1997,20:124-128
[5] Martinsen B,Horsberg T E.Comparative single-dose pharmacokinetics of four quinolones,oxolinic acid,flumequine,sarafloxacin,and enrofloxacin,in Atlantic salmon(Salmo salar)held in seawater at 10 ℃[J].Antimicrobial Agents and Chemotherapy,1995,39:1059-1064
[6] della Rocca G,Di Salvoa A,Malvisia J,et al.The disposition of enrofloxacin in seabream(Sparus aurata L.)after single intravenous injection or from medicatedfeed administration[J].Aquaculture,2004,232:53-62
[7] Intorre L,Cecchini S,Bertini S,et al.Pharmacokinetics of enrofloxacin in the seabass(Dicentrarchus labrax)[J].Aquaculture,2000,182:49-59
[8] 吴光红,张静波,孟勇,等.不同水温下恩诺沙星在中华绒螯蟹体内药物代谢动力学[J].南京农业大学学报,2008,31(2):105-110
[9] 方星星,王群,李健.恩诺沙星及其代谢产物环丙沙星在中国对虾体内的药代动力学[J].水产学报,2004,28(增刊):35-41
[10] 张菊香.建立禽畜水产品中之喹诺酮类药物分析方法及恩诺沙星在罗非鱼中药物动力学之研究.台北:台湾国立中山大学,2009:89-102
[11] Davies N M,Takemoto J K,Brocks D R,et al.Multiple peaking phenomena in pharmacokinetic disposition[J].Clinical Pharmacokinetics,2010,49(6):351-377
[12] Martinez M,McDermott P,Walker R.Pharmacology of the fluoroquinolones:a perspective for the use in domestic animals[J].Veterinary Journal,2006,172:10-18
[13] Roberts M S,Magnusson B M,Burczynski F J,et al.Enterohepatic circulation physiological,pharmacokinetic and clinical implications[J].Clinical Pharmacokinetics,2002,41(10):751-790
[14] Stoffregen D A,Wooster G A,Bustos P S,et al.Multiple route and dose pharmacokinetics of enrofloxacin in juvenile Atlantic salmon[J].Journal of Veterinary Pharmacology and Therapeutics,1997,20:111-123
[15] 房文红,于慧娟,蔡友琼,等.恩诺沙星及其代谢物环丙沙星在欧洲鳗鲡体内的代谢动力学[J].中国水产科学,2007,14(4):622-629
[16] Lucchetti D,Fabrizi L,Guandalini E,et al.Long depletion time of enrofloxacin in rainbow trout(Oncorhynchus mykiss)[J].Antimicrobial Agents Chemother,2004,48(10):3912-3917
[17] Zhanel G G.Influence of pharmacokinetic and pharmacodynamic principles on antibiotic selection[J].Current Infectious Disease Report,2001,3(1):29-34
[18] 张雨菡,姚杰,陆承平,等.人工诱导猪链球菌氟喹诺酮耐药株的靶位突变分析[J].南京农业大学学报,2009,32(4):133-137
[19] Martinsen B,Oppegaard H,Wichstrom R,et al.Temperature-dependent in vitro antimicrobial activity of four 4-quinolones and oxytetracycline against bacteria pathogenic tofish[J].Antimicrobial Agents and Chemotherapy,1992,36:1738-1743
[20] 王志强,朱琳.动物专用氟喹诺酮类药物对嗜水气单胞菌与温和气单胞菌的抗菌活性[J].中兽医医药杂志,2005,24(2):34-36

相似文献/References:

[1]张雨菡,姚杰,陆承平,等.人工诱导猪链球菌氟喹诺酮耐药株的靶位突变分析[J].南京农业大学学报,2009,32(4):133.[doi:10.7685/j.issn.1000-2030.2009.04.025]
 ZHANG Yu-han,YAO Jie,LU Cheng-ping,et al.Mutation analysis of induced fluoroquinolone-resistant mutants of Streptococcus suis in vitro[J].Journal of Nanjing Agricultural University,2009,32(4):133.[doi:10.7685/j.issn.1000-2030.2009.04.025]
[2]刘波,刘文斌,王恬.地衣芽孢杆菌对异育银鲫消化机能和生长的影响[J].南京农业大学学报,2005,28(4):80.[doi:10.7685/j.issn.1000-2030.2005.04.018]
[3]刘文斌,周岩民.饵料中添加酶制剂对异育银鲫消化和增重的影响[J].南京农业大学学报,1999,22(3):57.[doi:10.7685/j.issn.1000-2030.1999.03.015]
 Liu Wenbin,Zhou Yanmin.Effects of different enzyme levels in the diet on digestion and gain of Allogynogenetic crucian carp[J].Journal of Nanjing Agricultural University,1999,22(4):57.[doi:10.7685/j.issn.1000-2030.1999.03.015]
[4]郭凡溪,刘腾飞,耿智霞,等.复方甘草酸单铵可溶性粉对恩诺沙星联合LPS致鸡肝损伤保护机制研究[J].南京农业大学学报,2013,36(2):115.[doi:10.7685/j.issn.1000-2030.2013.02.019]
 GUO Fanxi,LIU Tengfei,GENG Zhixia,et al.Protective effects of compound ammonium glycyrrhizin soluble powder on liver injury induced by LPS and enrofloxacin in chickens[J].Journal of Nanjing Agricultural University,2013,36(4):115.[doi:10.7685/j.issn.1000-2030.2013.02.019]
[5]任伟龙,张瑜,钱晨韵,等.不同剂量黄连素对肉鸡组织P-gp编码基因Abcb1 mRNA表达及口服恩诺沙星药动学的影响[J].南京农业大学学报,2016,39(3):488.[doi:10.7685/jnau.201507036]
 REN Weilong,ZHANG Yu,QIAN Chenyun,et al.The effect of berberine on the pharmacokinetics of oral enrofloxain in broilers[J].Journal of Nanjing Agricultural University,2016,39(4):488.[doi:10.7685/jnau.201507036]
[6]王珏,徐佳迎,程粟裕,等.光谱法和分子对接研究3种兽医临床常用抗菌药对脲酶的影响及作用机制[J].南京农业大学学报,2020,43(4):690.[doi:10.7685/jnau.201909037]
 WANG Jue,XU Jiaying,CHENG Suyu,et al.The effects and mechanisms of three typical veterinary antimicrobials on the activity of urease studied by spectroscopic and molecular docking methods[J].Journal of Nanjing Agricultural University,2020,43(4):690.[doi:10.7685/jnau.201909037]

备注/Memo

备注/Memo:
收稿日期:2011-11-28;改回日期:。
基金项目:农业部水生动物遗传育种和养殖生物学重点开放实验室开放基金(BZ2007-04)
作者简介:方星星,博士研究生,讲师,主要从事水产动物药理与营养免疫研究,E-mail:fangxx@njau.edu.cn。
通讯作者:陆承平,教授, E-mail:lucp@njau.edu.cn。
更新日期/Last Update: 1900-01-01