[1]徐同锏,钟刚,王希春,等.脂肪包被γ-氨基丁酸对持续热应激奶牛HPA轴和部分免疫指标的影响[J].南京农业大学学报,2014,37(1):127-132.[doi:10.7685/j.issn.1000-2030.2014.01.021]
 XU Tongjian,ZHONG Gang,WANG Xichun,et al.Effects of lipid coated γ-aminobutyric acid on HPA axis and some immune indicators of cows in heat stress[J].Journal of Nanjing Agricultural University,2014,37(1):127-132.[doi:10.7685/j.issn.1000-2030.2014.01.021]
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脂肪包被γ-氨基丁酸对持续热应激奶牛HPA轴和部分免疫指标的影响()
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《南京农业大学学报》[ISSN:1000-2030/CN:32-1148/S]

卷:
37卷
期数:
2014年1期
页码:
127-132
栏目:
出版日期:
2014-01-10

文章信息/Info

Title:
Effects of lipid coated γ-aminobutyric acid on HPA axis and some immune indicators of cows in heat stress
作者:
徐同锏12 钟刚13 王希春1 吴金节1 李锦春1
1. 安徽农业大学动物科技学院, 安徽 合肥 230036;
2. 北京伟嘉集团公司, 北京 100085;
3. 天津宝迪农业科技股份有限公司, 天津 301800
Author(s):
XU Tongjian12 ZHONG Gang13 WANG Xichun1 WU Jinjie1 LI Jinchun1
1. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China;
2. Bejing Vica Group Comanpy, Bejing 100085, China;
3. Tianjin Baodi Agriculture Technologies Co.Ltd., Tianjin 301800, China
关键词:
脂肪包被γ-氨基丁酸热应激奶牛HPA轴免疫
Keywords:
lipid coated γ-aminobutyric acidheat stresscowHPA axisimmune
分类号:
S856
DOI:
10.7685/j.issn.1000-2030.2014.01.021
摘要:
为了解脂肪包被γ-氨基丁酸(GABA)对奶牛持续热应激的缓解效果,选用20头荷斯坦奶牛,随机均分为4组,每组5头,Ⅰ(对照组)、Ⅱ、Ⅲ、Ⅳ组分别饲喂脂肪包被GABA(40%纯度)0、5、10和15 g·d-1。结果表明:饲喂15 d,各试验组血清GABA水平均高于Ⅰ组,且Ⅳ与Ⅰ组间差异显著(P<0.05);Ⅲ、Ⅳ组的促肾上腺激素释放激素(CRH)显著低于Ⅰ、Ⅱ组;Ⅳ组白介素(IL-2)显著高于其他3组;Ⅳ组IgG极显著高于Ⅰ、Ⅱ组(P<0.01)。饲喂30 d,Ⅲ、Ⅳ组血清GABA极显著高于Ⅰ、Ⅱ组;Ⅳ组促肾上腺激素(ACTH)极显著低于Ⅰ组;Ⅳ组皮质醇(COR)显著低于Ⅰ和Ⅱ组;Ⅳ组IL-2显著高于Ⅰ组;Ⅲ和Ⅳ组IgM显著高于Ⅰ组。添加脂肪包被GABA降低了奶牛直肠温度和呼吸频率,且在10和30 d,Ⅲ、Ⅳ组直肠温度极显著低于Ⅰ组,Ⅳ组呼吸频率显著低于Ⅰ组。结论:添加脂肪包被GABA,抑制了HPA轴激素的分泌,增强了机体的免疫力,其中以添加GABA 15 g·d-1效果最好。
Abstract:
To investigate the alleviate effect of lipid coated γ-aminobutyric acid(GABA)on the continuous heat stress of cow,20 Holstein cows were selected and randomly divided into four groups with five replicates in each group,control groupⅠ,experimental group Ⅱ,Ⅲ and Ⅳ.The four groups were fed lipid coated GABA(40% purity)at the amount of 0,5,10 and 15 g·d-1,respectively.The results showed that the serum GABA concentration of each experimental group was higher than that of control group after 15 days and group Ⅳ was significantly different between groupⅠ(P<0.05);The concentrations of adrenocorticotropic hormone releasing hormone(CRH)of group Ⅲ and Ⅳ were significantly less than those of groupⅠand Ⅱ(P<0.05);The serum IL-2 concentration of group Ⅳ was significantly higher than those of the other three groups(P<0.05);The serum IgG concentration of group Ⅳ was extremely significantly higher than those of groupⅠand Ⅱ(P<0.01).The serum GABA concentration of group Ⅲ and Ⅳ were extremely significantly higher than those of groupⅠand Ⅱ after 30 days;The serum adrenocorticotropic hormone(ACTH)concentration of group Ⅳ was markedly significantly lower than those of groupⅠ;The serum corticosterone(COR)concentration of group Ⅳ was significantly lower than those of groupⅠand Ⅱ;The serum IL-2 concentration of group Ⅳ was significantly higher than that of groupⅠ(P<0.05);The serum IgM concentration of group Ⅲ and Ⅳ were significantly higher than that of groupⅠ(P<0.05).The rectal temperature and respiratory rate of cows were reduced with the addition of the coated GABA,and in the 10 and 30 days,the rectal temperature of group Ⅲ and Ⅳ was markedly significantly lower than that of groupⅠ(P<0.01),the respiratory rate of group Ⅳ was significantly lower than that of groupⅠ.Conclusion:The hypothalamus-pituitary gland-adrenal gland(HPA)axis hormone production and the body immunity were enhanced by feeding coated.Feeding 15 g·d-1 of GABA has the best effect in this experiment.

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备注/Memo

备注/Memo:
收稿日期:2013-1-11;改回日期:。
基金项目:安徽省现代奶牛产业技术体系项目(皖农科(2009)109号)
作者简介:徐同锏,硕士研究生。
通讯作者:李锦春,副教授,研究方向为营养代谢和中毒病及兽医临床诊疗技术,E-mail:jinchunli64@163.com。
更新日期/Last Update: 1900-01-01